Clinical Trials

A Beta-only IL-2 ImmunoTherapY Study (ABILITY-1)

NCT 05086692 Brief Summary This is a Phase 1/2, multi-center, open-label, dose-escalation…

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A Centralized Platform study for Functional High Risk Multiple Myeloma: Domain 1

ACTRN 12625000438459 Brief Summary The purpose of this platform study is to…

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A Clinical Study of IBI130 for Subjects With Unresectable, Locally Advanced or Metastatic Solid Tumors

NCT 05923008 Brief Summary This is a phase 1/2 multicenter, open-label, first-in-human…

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A Clinical Study of V940 and BCG in People With Bladder Cancer (V940-011/​INTerpath-011)

NCT 06833073 Brief Summary Researchers are looking for new ways to treat…

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A Clinical Study of V940 Treatment and Pembrolizumab in People With Bladder Cancer (V940-005/​INTerpath-005)

NCT 06305767 Brief Summary Researchers are looking for new ways to treat…

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A Clinical Study to Evaluate the Safety, Tolerability and Efficacy of IOS-1002 Administered Alone and in Combination with Pembrolizumab, a PD-1 Monoclonal Antibody in Advanced Solid Tumors

NCT 05763004 Brief Summary The goal of this clinical trial is to…

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A clinical trial to assess the safety, distribution, effects on certain immune cells and anti-leukaemia effects of LAVA-1266 in patients with acute myeloid leukaemia or certain types of myelodysplastic syndrome

ACTRN 12624001214527 Brief Summary This study is a first in human (FIH)…

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A Dose-Escalation and Expansion Study of BGB-16673 in Participants With B-Cell Malignancies (CaDAnCe-101)

NCT 05006716 Brief Summary Study consists of two main parts to explore…

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A First-in-human Dose Escalation and Expansion Study to Evaluate the Safety, and Tolerability of AZD8421 Alone or in Combination in Participants With Selected Advanced or Metastatic Solid Tumors (CYCAD-1)

NCT 06188520 Brief Summary This study is designed to evaluate AZD8421 alone…

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A First-in-Human Study of BG-C137, an Anti-FGFR2b Antibody Drug Conjugate, in Participants With Advanced Solid Tumors

NCT 06625593 Brief Summary The purpose of this study is to evaluate…

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A First-in-Human Study of BGB-C354 Alone and in Combination With Tislelizumab in Participants With Advanced Solid Tumors

NCT 06422520 Brief Summary This is a first-in-human, Phase 1a/1b study to…

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A First-in-human Study to Learn How Safe BAY 3713372 is and How it Works in Participants With MTAP-deleted Solid Tumors

NCT 06914128 Brief Summary The study treatment, BAY 3713372, is under development…

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A Global Study of Volrustomig (MEDI5752) Plus Chemotherapy Versus Pembrolizumab Plus Chemotherapy for Participants With Metastatic Non-small Cell Lung Cancer. (eVOLVE-Lung02)

NCT 05984277   Brief Summary The purpose of eVOLVE-Lung02 is to test…

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A Master Protocol (LY900023) That Includes Several Clinical Trials of Drugs for Children and Young Adults With Cancer (CAMPFIRE)

NCT 05999994 Brief Summary The main purpose of the master is to…

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A Modular, Multi-part, Multi-arm, Open-label, Phase I/II Study to Evaluate the Safety and Tolerability of GRWD5769 Alone and in Combination with Anticancer Treatments in Patients with Solid Malignancies – Module 2.

ACTRN 12623001077651 Brief Summary This study aims to assess a new cancer…

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A modular, multi-part, multi-arm, open-label, Phase I/II Study to evaluate the safety and tolerability of GRWD5769 in patients with solid malignancies – Module 1.

ACTRN 12623000108617 Brief Summary This study aims to assess a new cancer…

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A multi-centre, open label phase 2 trial investigating the effect of evolocumab in addition to chemotherapy or androgen receptor signalling inhibitor therapy on the circulating lipid profile of men with metastatic castration-resistant prostate cancer

ACTRN 12622001003763 Brief Summary Elevated lipids called ceramides are associated with poorer…

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A multicentre, open-label, Phase I study investigating the safety, tolerability, and efficacy of 177Lu-SSO110 with 68Ga-SSO120 companion imaging in participants with extensive stage small cell lung cancer (ES-SCLC) who are on maintenance treatment with immune checkpoint inhibition (The LuSato1 Study).

ACTRN 12623000185662 Brief Summary This study aims to assess the safety and…

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A Multicentre, Phase 1 Study Investigating the Safety, Tumor Uptake, Biodistribution, and Dosimetry of 68Ga-A9T-3202 in Participants with Locally Advanced or Metastatic Melanoma

ACTRN 12624000085572 Brief Summary This study aims to assess the safety and…

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A Multicentre,Study of IBI133 in Subjects With Unresectable, Locally Advanced or Metastatic Solid Tumours

NCT 06170190 Brief Summary This is a multicentre, open-label, first-in-human, phase 1/2…

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A Phase 1 Study of AB521 Monotherapy and Combination Therapies in Renal Cell Carcinoma and Other Solid Tumors (ARC-20)

NCT 05536141 Brief Summary The purpose of this study is to evaluate…

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A Phase 1 Study of SSGJ-709 in Patients With Advanced Malignant Tumors

NCT 07016490 Brief Summary This study is an open-label phase I study…

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A Phase 1 Study of UB-VV111 With and Without Rapamycin in Relapsed/​Refractory CD19+ B-cell Malignancies

NCT 06528301 Brief Summary This study is a Phase 1 dose-escalation and…

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A phase 1 study to assess the safety of short-course treatment with venetoclax prior to non-myeloablative stem cell transplantation for patients with haematological malignancies.

ACTRN 12622000308796 Brief Summary The purpose of this study is to investigate…

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A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients with Solid Tumors (INVOKE)

NCT 06789172 Brief Summary The purpose of this study is to investigate…

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A Phase 1/​2 Study of [225Ac]-FPI-1434 Injection

NCT 03746431 Brief Summary This is a first-in-human Phase 1/2, non-randomized, multi-centre,…

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A Phase 1/2a Study of DB-1311/BNT324 in Advanced/Metastatic Solid Tumors

NCT 05914116 Brief Summary This is a dose-escalation and dose-expansion Phase 1/2a…

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A Phase 1/2a, First-In-Human, Single and Multiple Ascending Dose Escalation and Dose Expansion Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Clinical Efficacy of Intralesional FLD-103 in Subjects with Basal Cell Carcinoma (BCC)

ACTRN 12624001138572 Brief Summary This study aims to determine the safety, tolerability…

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A Phase 1a/​1b Study of ELVN-001 for the Treatment Chronic Myeloid Leukemia (CML)

NCT 05304377 Brief Summary The purpose of this study is to evaluate…

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A Phase 1a/1b, first-in-human, open-label, non-randomised, multicenter, dose-escalation and dose -expansion study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of AXA-042 as monotherapy and in combination with an anti-PD-1 monoclonal antibody (cemiplimab) in subjects with advanced solid tumours: phase 1a

ACTRN 12622000993796 Brief Summary AXA-042 functions through a multi-cellular mechanism to re-engage…

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A phase 1a/b dose-escalation and dose-expansion study to evaluate Lutetium-177-PSMA I&T (Lu-PSMA) with radiosensitising Capecitabine in patients with metastatic castration-resistant prostate cancer (mCRPC)

ACTRN 12623001072606 Brief Summary This study aims to assess the effect of…

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A Phase 1b/​2 Study of Sonrotoclax (BGB-11417) as Monotherapy and in Various Combinations With Dexamethasone Plus Carfilzomib, Dexamethasone Plus Daratumumab, and Dexamethasone Plus Pomalidomide in Multiple Myeloma

NCT 04973605 Brief Summary Study consists of two parts, a part 1…

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A Phase 2 Study of T-DXd in Patients With Selected HER2 Expressing Tumors (DPT02)

NCT 04482309 Brief Summary This is an open-label, multi-center, multi-cohort, Phase 2…

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A Phase 2 Study of WU-CART-007, an Anti-CD7 Allogeneic CAR-T Cell Therapy inT-Cell Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma

NCT 06514794 Brief Summary The main purpose of this study is to…

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A phase 2, open-label, single-arm sulfasalazine monotherapy trial of progression-free survival in patients with pancreatic adenocarcinoma

ACTRN 12621001347853 Brief Summary This study will assess the anti-cancer activity of…

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A Phase 3 Study of Pacritinib in Patients With Primary Myelofibrosis, Post Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis (PACIFICA)

NCT 03165734 Brief Summary This study (study ID PAC203 North America; PAC303…

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A Phase I Study of [225Ac]-AZD2284 in Patients With Metastatic Castration-Resistant Prostate Cancer

NCT 06879041 Brief Summary The main purpose of the study is to…

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A Phase I Study of the Safety of Autologous GD2-Specific Chimeric Antigen Receptor-Expressing T Cells in Children with Diffuse Midline Glioma

ACTRN 12622000675729 Brief Summary The aim of this study is to assess…

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A Phase I Study to Evaluate the Safety, Tolerability, Pharmacology, and Preliminary Efficacy of AT-0174 in Subjects with Advanced Solid Malignancies

ACTRN 12623000956606 Brief Summary This study will be conducted in two parts…

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A Phase I Study to Evaluate the Safety,Tolerability, Pharmacokinetics, and Efficacy of YL211 in Patients With Advanced Solid Tumors

NCT 06384352 Brief Summary This is a multicenter, open-label, Phase 1 study.…

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A Phase I, Open-Label Study of the Safety, Tolerability and Pharmacokinetics of RX108-A Tablet in Patients with Locally Advanced or Metastatic Solid Tumors

ACTRN 12623000307606 Brief Summary This study is investigating a new cancer treatment…

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A Phase I, Open-label, Multicenter, First in Human Study to Evaluate the Safety and Tolerability of HH3806 in Patients with Advanced Malignancies

ACTRN 12622001339741 Brief Summary This is a first in human study of…

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A Phase I/​II, Dose Finding and Optimization Study of [177Lu]Lu-NeoB in Combination With Capecitabine in Patients With GRPR+, ER+, HER2- Metastatic Breast Cancer After Progression on Previous Endocrine Therapy in Combination With a CDK4/​6 Inhibitor. (NeoB-Cap1)

NCT 06247995 Brief Summary In the phase I part, to determine the…

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A phase I/II, open label, multi-centre study to assess the safety, tolerability, and efficacy of MG010 in combination with sorafenib in subjects with solid tumours who have failed existing treatments.

ACTRN 12620000849998 Brief Summary This purpose of this study is to determine…

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A Phase I/​IIa Study of AZD8205 Given Alone or in Combination With Anticancer Drugs, in Participants With Advanced or Metastatic Solid Malignancies

NCT 05123482 Brief Summary This research study is studying a new compound,…

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A Phase Ib/II Study of APG-2449 in Combination with Doxorubicin Hydrochloride Liposome in Patients with Ovarian Cancer

ACTRN 12623000174684 Brief Summary This study aims to establish the safety and…

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A Phase II Trial of Teclistamab in Participants With Previously Treated Immunoglobulin Light-chain (AL) Amyloidosis

NCT 06649695 Brief Summary This is a multicenter open-label, phase 2 study…

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A Phase II Trial to Evaluate Progression-Free Survival in Integrating Local Ablative Therapy with First-Line Systemic Treatment for Unresectable Oligometastatic Colorectal Cancer

ACTRN 12621001198819 Brief Summary This study aims to assess the clinical benefit…

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A Phase Ⅲ Clinical Study of HLX22 in Combination With Trastuzumab and Chemotherapy for the Treatment of Gastroesophageal Junction and Gastric Cancer

NCT 06532006 Brief Summary This is a double-blind, randomized, multiregion, comparative phase…

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A Phase Ⅲ Study of Rilvegostomig in Combination With Fluoropyrimidine and Trastuzumab Deruxtecan as the First-line Treatment for HER2-positive Gastric Cancer

NCT 06764875 Brief Summary This is a Phase Ⅲ, randomized, open-label, Sponsor-blinded,…

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A pilot study of Perindopril in combination with first line Ipilimumab and Nivolumab for patients with unresectable or metastatic melanoma- ACE-IT 001

ACTRN 12621000156886 Brief Summary This study is investigating whether it is safe…

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A Prospective, Multi-Centre Trial of TKI Redifferentiation Therapy in Patients With RAIR Thyroid Cancer (I-FIRST Study) (I-FIRST)

NCT 05182931 Brief Summary This prospective, multi-centre, open label, non-randomised phase II…

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A randomised controlled trial of Standard Of Care versus RadioAblaTion in Early Stage HCC (The SOCRATES HCC Study)

ACTRN 12621001444875 Brief Summary The SOCRATES HCC study aims to investigate whether…

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A safety and early efficacy study of LSTA1 in combination with durvalumab, gemcitabine and nab-paclitaxel, as first-line treatment in locally advanced pancreatic ductal adenocarcinoma (PDAC)

ACTRN 12623000223639 Brief Summary This study aims to assess the safety and…

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A Safety and Pharmacokinetics Study of RC220 Combined With Doxorubicin in Adult Participants With Solid Tumours.

NCT 06815575 Brief Summary This is a multi-centre, two-part, open-label, phase 1,…

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A single arm, open label, signal seeking, phase II trial of the activity of Durvalumab in combination with Acalabrutinib in patients with high-grade B cell lymphoma

ACTRN 12621000507886 Brief Summary This is a substudy of the Cancer Molecular…

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A Study Comparing Talquetamab Plus Pomalidomide, Talquetamab Plus Teclistamab, and Elotuzumab, Pomalidomide, and Dexamethasone or Pomalidomide, Bortezomib, and Dexamethasone in Participants With Relapsed or Refractory Myeloma Who Have Received an Anti-CD38 Antibody and Lenalidomide (MonumenTAL-6)

NCT 06208150   Brief Summary The purpose of this study is to…

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A Study Comparing Tarlatamab, Durvalumab, Carboplatin, and Etoposide Versus Durvalumab, Carboplatin, and Etoposide in First-line Extensive Stage Small-Cell Lung Cancer (ES-SCLC) (DeLLphi-312)

NCT 07005128 Brief Summary The main objective of the study is to…

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A Study Evaluating Sotorasib Platinum Doublet Combination Versus Pembrolizumab Platinum Doublet Combination as a Front-Line Therapy in Participants With Stage IV or Advanced Stage IIIB/​C Nonsquamous Non-Small Cell Lung Cancers (CodeBreaK 202)

NCT 05920356   Brief Summary The primary objective of this study is…

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A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Participants With Breast Cancer

NCT 04802759 Brief Summary This is a Phase Ib/II, open-label, multicenter, randomized…

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A Study Evaluating the Efficacy and Safety of Pirtobrutinib in Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia/​Small Lymphocytic Lymphoma

NCT 06588478 Brief Summary The main purpose of this study is to…

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A Study Evaluating the Safety and Efficacy of Multiple Treatments in Participants With Multiple Myeloma (PLYCOM)

NCT 05583617 Brief Summary CO43923 is a platform study that will evaluate…

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A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)

NCT 04929223 Brief Summary This open-label, exploratory study is designed to evaluate…

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A Study Evaluating the Safety, Activity, and Pharmacokinetics of Divarasib in Combination With Other Anti-Cancer Therapies in Participants With Previously Untreated Advanced or Metastatic Non-Small Cell Lung Cancer With a KRAS G12C Mutation (Krascendo 170)

NCT 05789082 Brief Summary The purpose of this study is to evaluate…

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A Study Evaluating the Safety, Pharmacokinetics, and Activity of the Combination of Cevostamab and Elranatamab in Participants With Relapsed or Refractory Multiple Myeloma (R/​R MM)

NCT 05927571 Brief Summary The purpose of the study is to evaluate…

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A Study Investigating BGB-26808 Alone or in Combination With Tislelizumab in Participants With Advanced Solid Tumors

NCT 05981703 Brief Summary This is an open-label, multicenter, and nonrandomized dose…

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A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)

NCT 06875310 Brief Summary This is a trial to evaluate the efficacy,…

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A Study of Adjuvant V940 and Pembrolizumab in Renal Cell Carcinoma (V940-004). (INTerpath-004)

NCT 06307431 Brief Summary The primary objective of the study is to…

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A Study of AK146D1 for Injection in the Treatment of Advanced Solid Tumors

NCT 06929663 Brief Summary This is an first-in-human, Phase I clinical study…

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A Study of AMG 193 in Participants With Advanced MTAP-null Solid Tumors (MTAPESTRY 101) (MTAPESTRY 101)

NCT 05094336 Brief Summary The primary objective of Parts 1 and 2…

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A Study of Amivantamab and FOLFIRI Versus Cetuximab/​Bevacizumab and FOLFIRI in Participants With KRAS/​NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy (OrigAMI-3)

NCT 06750094 Brief Summary The purpose of this study is to compare…

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A Study of AP402 in HER2-Positive Patients With Locally or Advanced Solid Tumors

NCT 06669975 Brief Summary This is a Phase 1/2, multi-regional, multi-center, open-label,…

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A Study of Avutometinib (VS-6766) + Defactinib (VS-6063) in Recurrent Low-Grade Serous Ovarian Cancer (RAMP 301)

NCT 06072781 Brief Summary This study will assess the safety and efficacy…

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A Study of AZD0486 in Subjects With Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma

NCT 04594642 Brief Summary This phase 1 study will investigate the safety,…

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A Study of AZD0486 Monotherapy or in Combination With Other Anti-Cancer Agents for Mature B-Cell Malignancies (Soundtrack-E)

NCT 06564038 Brief Summary The purpose of this study is to assess…

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A Study of AZD0486 Plus Rituximab in Previously Untreated Follicular Lymphoma Patients

NCT 06549595 Brief Summary This is a global, randomised, Phase III, multicentre,…

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A Study of AZD3470, a PRMT5 Inhibitor, in Patients With MTAP Deficient Advanced/​Metastatic Solid Tumors (PRIMROSE)

NCT 06130553 Brief Summary This is a first time in human (FTiH)…

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A Study of BGB-11417 in Participants With Myeloid Malignancies

NCT 04771130 Brief Summary The study will determine the safety, tolerability, recommended…

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A Study of BGB-16673 Compared to Investigator’s Choice in Participants With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Previously Exposed to Both Bruton Tyrosine Kinase (BTK) and B-cell Leukemia/​Lymphoma 2 Protein (BCL2) Inhibitors

NCT 06846671 Brief Summary The purpose of this study is to investigate…

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A Study of BGB-B455 in Adults With Advanced or Metastatic Solid Tumors

NCT 06803680 Brief Summary The goal of this clinical trial is to…

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A Study of CF33-hNIS (VAXINIA), an Oncolytic Virus, as Monotherapy or in Combination With Pembrolizumab in Adults With Metastatic or Advanced Solid Tumors (MAST)

NCT 05346484 Brief Summary This is an open-label, dose-escalation, multi-center phase I…

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A Study of Ciltacabtagene Autoleucel and Talquetamab for the Treatment of Participants With High-Risk Multiple Myeloma (MonumenTAL-8)

NCT 06550895   Brief Summary The purpose of this study is to…

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A Study of CNA3103 (LGR5-targeted, Autologous CAR-T Cells) Administered to Subjects With Metastatic Colorectal Cancer

NCT 05759728 Brief Summary This study aims to determine the safety and…

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A Study of Combination Chemotherapy for Patients With Newly Diagnosed DAWT and Relapsed FHWT

NCT 04322318  Brief Summary This phase II trial studies how well combination…

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A Study of CS5001 in Patients With Advanced Solid Tumors and Lymphoma

NCT 05279300 Brief Summary This is a first-in-human (FIH) study to evaluate…

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A Study of D3S 001 Monotherapy or Combination Therapy in Subjects With Advanced Solid Tumors With a KRAS p.G12C Mutation

NCT 05410145 Brief Summary This is a first-in-human (FIH), multicenter, open-label, dose-escalation,…

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A Study of DB-1303/​BNT323 vs Investigator’s Choice Chemotherapy in HER2-Low, Hormone Receptor Positive Metastatic Breast Cancer (DYNASTY-Breast02)

NCT 06018337 Brief Summary The goal of this clinical trial is to…

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A Study of Dostarlimab vs Placebo After Chemoradiation in Adult Participants With Locally Advanced Unresected Head and Neck Squamous Cell Carcinoma (JADE)

NCT 06256588 Brief Summary The goal of this study is to assess…

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A Study of DR-0201 in Subjects With Relapsed/​Refractory B-Cell Non-Hodgkin Lymphoma

NCT 06392477 Brief Summary This is a multicenter, multiple expansion cohort, Phase…

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A study of EnGeneIC Dream Vectors (EDV’s) packaged with the chemotherapy, E-EDV-D682 given simultaneously as non-targeted EDVs carrying an immune enhancer called EDV-GC, in participants with advanced epidermal growth factor expressing cancers whose disease has progressed after one or two treatment regimes, or where other standard therapies are not appropriate. (EGFR EDV-D682/GC Trial)

ACTRN 12625000203459 Brief Summary This study aims to determine whether E-EDV-D682 in…

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A Study of Ficlatuzumab in Combination With Cetuximab in Participants With Recurrent or Metastatic (R/​M) HPV Negative Head and Neck Squamous Cell Carcinoma (FIERCE-HN)

NCT 06064877   Brief Summary The purpose of this study is to…

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A Study of GSK5764227 in Participants With Relapsed Small Cell Lung Cancer (SCLC)

NCT 07099898 Brief Summary “In this study researchers are testing GSK5764227, a…

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A Study Of IMM47 In Subjects With Advanced Solid Tumors

NCT 05985083 Brief Summary This is a first-in-human (FIH), open-label, multi-center, phase…

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A Study of Izalontamab Brengitecan Versus Chemotherapy in Participants With Previously Untreated, Locally Advanced, Recurrent Inoperable, or Metastatic Triple-negative Breast Cancer Ineligible for Anti-PD(L)1 Drugs (IZABRIGHT-Breast01)

NCT 06926868 Brief Summary The purpose of this study is to assess…

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A Study of JNJ-78278343 in Combination With Either JNJ-63723283 (Cetrelimab), Taxane Chemotherapy, or Androgen Receptor Pathway Inhibitors for Metastatic Castration-Resistant Prostate Cancer

NCT 05818683 Brief Summary The purpose of this study is to identify…

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A Study of JNJ-79635322 in Combination With Daratumumab or Pomalidomide for Multiple Myeloma

NCT 06768489 Brief Summary The primary purpose of this study for Part…

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A Study of JNJ-87801493 in Combination With T-Cell Engagers in Participants With B-cell Non-Hodgkin Lymphoid (NHLs) Cancer

NCT 06139406 Brief Summary The purpose of this study is to characterize…

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A Study of KER-050 to Treat Anemia Due to Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes

NCT 04419649 Brief Summary The purpose of this study is to evaluate…

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A Study of MT-303 in Adults With Advanced or Metastatic GPC3-Expressing Cancers, Including HCC

NCT 06478693 Brief Summary This is a multicenter, open-label, Phase 1, first-in-human,…

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A Study of Narmafotinib Given in Combination With Modified FOLFIRINOX in Patients With Metastatic Pancreatic Cancer

NCT 07026279 Brief Summary This study is testing narmafotinib, a type of…

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A Study of Nemtabrutinib Plus Venetoclax vs Venetoclax + Rituximab (VR) in Second-line (2L) + Relapsed/​Refractory (R/​R) Chronic Lymphocytic Leukemia/​Small Lymphocytic Lymphoma (CLL/​SLL) (MK-1026-010/​BELLWAVE-010).

NCT 05947851 Brief Summary The purpose of this study is to assess…

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A Study of Novel Study Interventions and Combinations in Participants With Colorectal Cancer (CANTOR)

NCT 06792695 Brief Summary The main purpose of this study is to…

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A Study of NVL-655 in Patients With Advanced NSCLC and Other Solid Tumors Harboring ALK Rearrangement or Activating ALK Mutation (ALKOVE-1)

NCT 05384626 Brief Summary Phase 1/2, dose escalation and expansion study designed…

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A Study of Olverembatinib in SDH-deficient GIST

NCT 06640361 Brief Summary An international multicenter, open, single-arm pivotal registration phase…

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A study of opaganib in addition to darolutamide in participants with metastatic hormone resistant prostate cancer, selected for the presence of a specific biomarker.

ACTRN 12624001458527 Brief Summary This study is taking a novel approach to…

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A Study of Pimitespib in Combination with Imatinib in Patients with GIST (CHAPTER-GIST-101)

NCT 05245968   Brief Summary This study consists of Dose escalation part…

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A Study of PRT7732, an Oral SMARCA2 Degrader, in Patients With Advanced or Metastatic Solid Tumors With a SMARCA4 Mutation

NCT 06560645 Brief Summary This is a Phase 1 study to determine…

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A Study of RAG-01 in Patients With Non-muscle-invasive Bladder Cancer (NMIBC) Who Have Failed Bacillus Calmette Guérin (BCG) Therapy

NCT 06351904   Brief Summary This is an open label, multi-center study…

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A Study of Ripretinib vs Sunitinib in Patients With Advanced GIST With Specific KIT Exon Mutations Who Were Previously Treated With Imatinib (INSIGHT)

NCT 05734105 Brief Summary This is a Phase 3, 2-arm, randomized, open-label,…

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A Study of SR-8541A (ENPPI Inhibitor) in Advanced/​Metastatic Solid Tumors

NCT 06063681 Brief Summary This is an open-label, dose-escalation, multi-center phase 1…

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A Study of Tagraxofusp in Combination With Venetoclax and Azacitidine in Adults With Untreated CD123+ Acute Myeloid Leukemia Who Cannot Undergo Intensive Chemotherapy

NCT 06456463 Brief Summary This study will be divided into 2 parts…

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A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer (MOUNTAINEER-03)

NCT 05253651   Brief Summary This study is being done to find…

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A Study of ZN-c3 in Patients With Ovarian Cancer

NCT 04516447 Brief Summary This is a Phase 1b open-label, multicenter study,…

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A Study to Assess the Effect of Venetoclax on Ethinyl Estradiol and Levonorgestrel in Female Participants With Different Hematological Malignancies

NCT 03557619 Brief Summary A study to assess the effect of multiple…

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A Study to Assess the Efficacy and Safety of FORE8394 in Participants With Cancer Harboring BRAF Alterations

NCT 05503797 Brief Summary The objective of this Master Protocol is to…

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A Study to Assess the Safety, Pharmacokinetics, Pharmacodynamics, and Preliminary Efficacy of ATG 037 Monotherapy and Combination Therapy With Pembrolizumab in Patients With Advanced Solid Tumors

NCT 05205109 Brief Summary This is a study of ATG-037 Monotherapy and…

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A Study to Compare the Efficacy and Safety of BMS-986365 Versus the Investigator’s Choice of Therapy in Participants With Metastatic Castration-resistant Prostate Cancer (rechARge)

NCT 06764485 Brief Summary The purpose of this study is to compare…

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A Study to Compare the Efficacy and Safety of Golcadomide in Combination With Rituximab (Golca + R) vs Investigator’s Choice in Participants With Relapsed/​Refractory Follicular Lymphoma (GOLSEEK-4)

NCT 06911502 Brief Summary The study is designed as a multicenter, randomized,…

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A Study to Evaluate a Novel Gene Therapy in Patients With Relapsed and Refractory Multiple Myeloma (inMMyCAR)

NCT 07075185 Brief Summary The goal of this clinical trial is to…

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A Study to Evaluate Efficacy and Safety of Giredestrant Compared With Fulvestrant (Plus a CDK4/​6 Inhibitor), in Participants With ER-Positive, HER2-Negative Advanced Breast Cancer Resistant to Adjuvant Endocrine Therapy (pionERA Breast Cancer)

NCT 06065748 Brief Summary This is a Phase III, randomized, open-label multicenter…

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A Study to Evaluate INCA033989 Administered as a Monotherapy or in Combination With Ruxolitinib in Participants With Myeloproliferative Neoplasms

NCT 05936359   Brief Summary This study is being conducted to evaluate…

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A Study to Evaluate INCA035784 in Participants With Myeloproliferative Neoplasms

NCT 07008118 Brief Summary This study is being conducted to evaluate the…

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A Study to Evaluate KIN-2787 in Participants With BRAF and/​or NRAS Mutation Positive Solid Tumors

NCT 04913285 Brief Summary The purpose of this study is to evaluate…

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A Study to Evaluate Neoadjuvant Sonidegib Followed by Surgery or Imiquimod in the Management of Basal Cell Carcinoma (SONIB)

NCT 03534947 Brief Summary In this study, patients with BCC will be…

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A Study to Evaluate Safety and Efficacy of Bomedemstat (MK-3543-017)

NCT 06351631 Brief Summary The primary purpose of the study is to…

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A Study to Evaluate Safety, PK, PD and Efficacy of AZD5492, a T Cell-engaging Antibody Targeting CD20 in Subjects With R/​R B-Cell Malignancies. (TITANium)

NCT 06542250 Brief Summary This is a Phase I/II study designed to…

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A Study to Evaluate the Benefit of Adding Durvalumab After Chemotherapy, Durvalumab and Surgery in Patients With Early-stage, Operable, Non-small Cell Lung Cancer.

ACTRN 12624001373561 Brief Summary The aim of this study is to determine…

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A Study to Evaluate the Efficacy and Safety of Autogene Cevumeran With Nivolumab Versus Nivolumab Alone in Participants With High-Risk Muscle-Invasive Urothelial Carcinoma (MIUC) (IMCODE004)

NCT 06534983 Brief Summary The main purpose of the study is to…

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A Study to Evaluate the Efficacy and Safety of Autogene Cevumeran With Nivolumab Versus Nivolumab Alone in Participants With High-Risk Muscle-Invasive Urothelial Carcinoma (MIUC) (IMCODE004)

NCT 06534983 Brief Summary The main purpose of the study is to…

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A Study to Evaluate the Efficacy and Safety of Inavolisib in Combination With Phesgo Versus Placebo in Combination With Phesgo in Participants With PIK3CA-Mutated HER2-Positive Locally Advanced or Metastatic Breast Cancer

NCT 05894239   Brief Summary This study will evaluate the efficacy and…

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A Study to Evaluate the Safety, Pharmacokinetics, and Activity of RO7502175 as a Single Agent and in Combination With Checkpoint Inhibitor in Participants With Locally Advanced or Metastatic Solid Tumors

NCT 05581004 Brief Summary This is a first-in-human study to evaluate the…

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A Study to Evaluate the Safety, Pharmacokinetics, and Anti-Tumor Activity of RO7589831 as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumor

NCT 06004245 Brief Summary This is a first-in-human, Phase I, open-label, multicenter,…

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A Study to Evaluate the Safety, Pharmacokinetics, and Anti-Tumor Activity of RO7589831 as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors

NCT 06004245 Brief Summary This is a first-in-human, Phase I, open-label, multicenter,…

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A Study to Investigate Progression-Free Survival With Sonrotoclax Plus Obinutuzumab Or Sonrotoclax Plus Rituximab Compared With Venetoclax Plus Rituximab Treatment In Patients With Relapsed and/​or Refractory Chronic Lymphocytic Leukemia/​Small Lymphocytic Lymphoma (CELESTIAL-RRCLL)

NCT 06943872 Brief Summary The goal of this study is to compare…

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A Study to Investigate Safety of AZD6750 in Adult Participants With Select Advanced or Metastatic Solid Tumors

NCT 07115043 Brief Summary A Study to Investigate Safety of AZD6750 in…

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A Study to Investigate the Biological Effects of Saruparib (AZD5305), Darolutamide, and in Combination in Men With Newly Diagnosed Prostate Cancer. (ASCERTAIN)

NCT 05938270 Brief Summary A Study to Investigate the Biological Effects of…

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A Study to Investigate the Efficacy and Safety of Sonrotoclax Plus Zanubrutinib Compared With Placebo Plus Zanubrutinib in Adults With Relapsed/​Refractory Mantle Cell Lymphoma

NCT 06742996 Brief Summary The goal of this study is to compare…

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A Study to Investigate the Safety and Efficacy of NST-628 Oral Tablets in Subjects with Solid Tumors (NST-628)

NCT 06326411 Brief Summary This is a two-part Phase 1, open label,…

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A Study to Investigate the Safety of Novel Dose Ramp-up Schedule(s) When Initiating Sonrotoclax in Participants Treated for Blood Cancers.

NCT 06697184 Brief Summary The purpose of this study is to establish…

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A Study to Investigate the Safety, Pharmacokinetics, and Preliminary Effectiveness of GSK4418959 Alone or in Combination With Other Anti-cancer Agents in Participants With Solid Tumors (SYLVER)

NCT 06710847 Brief Summary Solid tumours are abnormal lumps of tissue that…

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A Study to Learn About Study Medicine ALTA2618 in Adults with AKT1 E17K-Mutant Solid Tumors

NCT 06533059 Brief Summary The purpose of this study is to characterize…

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A Study to Learn More About How Well BAY 2927088 Works and How Safe it is Compared With Standard Treatment, in Participants Who Have Advanced Non-small Cell Lung Cancer (NSCLC) With Mutations in the Genes of Human Epidermal Growth Factor Receptor 2 (HER2) (SOHO-02)

NCT 06452277 Brief Summary Researchers are looking for a better way to…

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A Study to Learn More About How Well Treatment With BAY2927088 Tablets Works and How Safe it is in Participants Who Have a Solid Tumor With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2) (panSOHO)

NCT 06760819 Brief Summary Researchers are looking for a better way to…

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A Trial of Palliative Chemotherapy, Radiation and Immune Treatment for Oesophageal Cancer: PALEO Study (PALEO)

NCT 06290505 Brief Summary The purpose of this study is to investigate…

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A Trial of Palliative Chemotherapy, Radiation and Immune Treatment for Oesophageal Cancer: PALEO Study (PALEO)

NCT 06290505 Brief Summary The purpose of this study is to investigate…

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A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent Glioblastoma (GBM AGILE)

NCT 03970447 Brief Summary Glioblastoma (GBM) adaptive, global, innovative learning environment (GBM…

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A TRIAL TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS, AND EFFICACY OF SHR-A1904 IN SUBJECTS WITH ADVANCED SOLID TUMORS

NCT 05277168 Brief Summary The study (dose escalation/expansion) is being conducted to…

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A Trial to Learn How the Combination of Fianlimab With Cemiplimab and Chemotherapy Works Compared With Cemiplimab and Chemotherapy for Treating Adult Patients With Advanced Non-small Cell Lung Cancer

NCT 05800015   Brief Summary This study is researching an investigational drug…

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Accelerated v’s Standard BEP Chemotherapy for Patients With Intermediate and Poor-risk Metastatic Germ Cell Tumours (P3BEP)

NCT 02582697 Brief Summary The purpose of this study is to determine…

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Active Surveillance, Bleomycin, Etoposide, Carboplatin or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors

NCT 03067181 Brief Summary This phase III trial studies how well active…

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ADCE-T02, a Tissue Factor Targeted Antibody-Drug Conjugate, in Patients With Selected Advanced Solid Tumours

NCT 06597721 Brief Summary Adcendo ApS is conducting a phase 1 study…

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Adding IL-2 to Tebentafusp to Eradicate Cancer Progression (SILVER)

NCT 07063875 Brief Summary A recent clinical trial found that after 36…

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Addition of prochlorperazine to paclitaxel, trastuzumab, and pertuzumab for previously untreated HER2-positive metastatic breast cancer: a phase 1 dose de-escalation study

ACTRN 12622000016730 Brief Summary Patients with previously untreated HER2-positive locally advanced or…

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AMG 193 Alone or in Combination With Other Therapies in Subjects With Advanced Thoracic Tumors With Homozygous MTAP-deletion (Master Protocol)

NCT 06333951 Brief Summary The study aims to determine maximum tolerated dose…

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AMLM26- INTERCEPT (Investigating Novel Therapy to Target Early Relapse and Clonal Evolution as Pre-emptive Therapy in AML): A Multi-arm, Precision-based, Recursive, Platform Trial – The Master Protocol

ACTRN 12621000439842 Brief Summary The aim is to demonstrate that targeting rising…

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AMT-116 in Patients With Advanced Solid Tumor

NCT 05725291 Brief Summary This first-in-human study will evaluate the Maximum Tolerated…

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AMT-151 in Patients With Selected Advanced Solid Tumours

NCT 05498597 Brief Summary This first-in-human study will evaluate the Maximum Tolerated…

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AMT-253 in Patients With Selected Advanced Solid Tumours

NCT 05906862 Brief Summary This first-in-human study will evaluate the Maximum Tolerated…

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An early phase, open label, multicentre, trial study to assess safety and efficacy of front-line therapy for EBV-associated Lymphomas 2 (TREBL-2) – ALLG NHL36

ACTRN 12622001189718 Brief Summary The purpose of this study is to assess…

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An Efficacy Study of Adjuvant Treatment With the Personalized Cancer Vaccine mRNA-4157 and Pembrolizumab in Participants With High-Risk Melanoma (KEYNOTE-942)

NCT 03897881 Brief Summary The purpose of this study is to assess…

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Anti-PD 1 Brain Collaboration + Radiotherapy Extension (ABC-X Study) (ABC-X)

NCT 03340129 Brief Summary This is a phase II, open label, randomised…

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APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors (SPARTA)

NCT 03175224 Brief Summary To assess: efficacy of APL-101 as monotherapy for…

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Autologous Tumour Vaccine Trial

NCT 05807035 Brief Summary Phase 1 trial to evaluate the feasibility of…

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AZD0305 as Monotherapy or in Combination With Anticancer Agents in Participants With Relapsed/​Refractory Multiple Myeloma

NCT 06106945   Brief Summary This is a Phase I/II, modular, open-label,…

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AZD0901 in Participants With Advanced Solid Tumours Expressing Claudin18.2

NCT 06219941 Brief Summary The purpose of this study is to assess…

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