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Feasibility of functional magnetic resonance Imaging GUided Radiation therapy dose Escalation in Head and Neck Cancer patients (FIGURE-pall HNC)

ACTRN 12625001075471

Brief Summary

This study is testing whether an advanced type of MRI scan (called diffusion weighted MRI) can be used to guide and safely increase radiation doses to “high-risk” areas of head and neck cancers, with the aim of improving tumour control while still protecting surrounding healthy tissue.

Intervention/Treatment

  • Radiation therapy

Inclusion Criteria

  1. Either:
    • Histologically or cytologically proven squamous cell carcinoma from a locally advanced mucosal primary in the head and neck region, or
    • Massive nodal metastases from an unknown primary suspected to be of head and neck origin.
  2. Ineligible for curative treatment on the basis of the extent of their disease and/or general medical condition.
  3. 18 years of age or older (no upper limit).
  4. Able to give informed consent to treatment by understanding the nature, significances and consequences of the study.

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