Brief Summary
The purpose of eVOLVE-Lung02 is to test the effectiveness (efficacy) and measure the safety of volrustomig in combination with chemotherapya cancer treatment that uses drugs to kill or slow the growth of cancer cells, while minimising damage to healthy cells compared with pembrolizumab in combination with chemotherapy as 1L treatment in participants with mNSCLC in PD-L1 < 50%.
Intervention / Treatment
- Drug: Volrustomig
- Drug: Pembrolizumab
- Drug: Carboplatin
- Drug: Paclitaxel
- Drug: Pemetrexed
Key Inclusion Criteria:
- Histologically or cytologically documented squamous or non-squamous NSCLC.
- Stage IV NSCLC (according to Version 8 of the IASLC Stagingthe process of determining how big the cancer is, where it started and if it has spread to other areas Manual in Thoracic Oncologythe study, diagnosis and treatment of cancer 2016), not amenable to curative surgerytreatment involving removal of cancerous tissue and/or tumours and a margin of healthy tissue around it to reduce recurrence or radiation.
- Absence of sensitizing EGFR mutations and ALK and ROS1 rearrangements.
- Absence of documented tumor genomic alteration results from tests conducted as part of standard local practice in any other actionable driver oncogenes for which there are locally approved targeted first-line therapies.