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Granulosa Tumours of the Ovary

To view this article in the new Rare Cancers Australia Knowledgebase, click here 

Granulosa tumours are rare tumours of the ovary. They are a type of stromal tumour. The stroma is the supportive tissue of the ovary. Out of 100 women with ovarian cancer, fewer than 5 will have a granulosa tumour (5%).

There are 2 main types of granulosa tumours:

  • Functioning tumours which produce hormones.
  • Non functioning tumours which don’t produce hormones.

Functioning tumours make the female hormone oestrogen. 

We don’t know what causes this type of cancer. Most cancers are caused by a number of different factors working together.

Symptoms of Granulosa Tumours

The symptoms of functioning tumours are usually hormone related. These symptoms include:

  • Menstrual changes (periods): If you are still having periods they may become irregular, they may be very heavy and you may bleed between periods.
  • Vaginal bleeding: If you have had your menopause the most common symptom is vaginal bleeding. This happens because the hormones the tumour produces makes the lining of the womb thicker. This means that you may also need some tests to check your womb as well.
  • Breast Tenderness: You may have breast tenderness and vaginal discharge due to the hormones.

Other symptoms of granulosa tumours can include:

  • Pain in the abdomen.
  • Swelling of the abdomen.
  • Constipation.
  • Passing urine more often than usual.

Treatment for Granulosa Tumours

The type of treatment you have will depend on:

  • Your age and whether you have been through the menopause.
  • Whether you want to have children.
  • The stage of your cancer.

Surgery

Surgery is the main treatment for this type of ovarian cancer, and for many women it is the only treatment you need.

If you have had your menopause, you will have your ovaries, fallopian tubes and womb removed. Doctors call this operation a bilateral salpingo oophorectomy (pronounced sal-pin-go-oo-for-eck-tom-ee) and total abdominal hysterectomy.

If the tumour is only in one ovary, you are still having periods and haven't yet had all the children you want to, your surgeon may be able to remove just the ovary affected by the cancer and the fallopian tube on that side. This will leave your womb and the other ovary intact.

During surgery the doctors will also check the rest of your abdominal area for cancer.

If the cancer comes back in the same area you may have more surgery, and possibly other treatments too.

Chemotherapy

Doctors use chemotherapy to treat more advanced cancer, or cancer that has come back and can’t be removed with surgery.

Generally, you have chemotherapy as a combination of 3 different drugs. Various different combinations are used but they all include a drug known as platinum. One of the more common chemotherapy ‘regimens’ is called BEP. This can also treat testicular cancer. All the drugs go into your bloodstream through a vein in your arm (intravenously) or through a central line.

Radiotherapy

You may have radiotherapy to treat the cancer if it comes back. It isn’t usually used as a first treatment.

After treatment

Women with early stage granulosa tumour have a low risk of the cancer coming back. So, if all is well once you have recovered from your surgery, your surgeon (gynaecological oncologist) may discharge you. They will make sure you know how to contact them again if you develop any symptoms in the future.

If your doctor wants to see you regularly for a time, this will be every few months at first. As time goes by it will become less often, if all is well. This follow up may continue for many years, as there is a chance the cancer can come back some years after treatment. Or your doctor may discharge you after a time, with instructions on contacting them if you have any concerns.

Follow up may involve having a blood test. Doctors use these blood tests to look for a marker in your blood. A marker is a substance produced by cancer cells that can be picked up in blood. The level of the marker goes up as the cancer grows.

A number of different markers can be raised with granulosa tumours. It is important to remember that these markers may be raised for reasons other than cancer. But checking for these markers, alongside other tests, can sometimes help to show if the cancer has come back. The markers doctors may use to check for granulosa tumours are called inhibin, CA125 and Müllerian inhibiting substance or MIS (also called anti mullerian hormone - AMH).

For more information on Ovarian Germ Cell Tumors click here

This link is to the Cancer Research UK cancer website in the United Kingdom. There may be references to drugs and clinical trials that are not available here in Australia.

For information about clinical trials that are available in Australia click here

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