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Clinical Trials 

Clinical trials are an essential part of the development of new treatments and help to improve the diagnosis, treatment and management of people with cancer.

RCA provides information about clinical trial registries and individual clinical trials with the hope that it assists you to be informed about what clinical trials are available. However, RCA is not responsible for the content or maintenance of these sites or specific clinical trial information. We will endeavor to keep this information up to date but the reader is ultimately responsible to check the accuracy of this information.

RCA neither recommends nor endorses any clinical trials. Patients are encouraged to complete their own research into any clinical trials and possible effects and impacts to their health as a result of such trials. It is the patient’s responsibility, in consultation with their medical professional, to determine whether they wish to take part in such trials.
 
Before you consider participation in any clinical trial you should seek advice from your medical professional. 

Clinical Trial Registries

Clinical trial registries allow you to find clinical trials in Australia. A registry is defined as an organisation or website that either:

  • Lists clinical trials being conducted (or that have recently been conducted) in Australia (or internationally, including Australia)
  • Provides a mechanism for patients or others to register their interest in participating in an Australian clinical trial
  • Provides a link between potential participants and Australian clinical trials.

For Clinical Trial Registries please visit australianclinicaltrials.gov.au.

Other clinical trial registries can be found by visiting these links:

http://www.australiancancertrials.gov.au/
http://www.cancervic.org.au/trials/
http://www.cancertrialsaustralia.com/
http://www.anzctr.org.au/

Other Clinical Trials

From time to time RCA is approached by clinicians who are involved with a clinical trial to share relevant information with the patient community. Details of these trials with contact information are below.

Trial Name: The Cancer Molecular Screening and Therapeutics (MoST) Program-Screening. (ACTRN12616000908437)
Location: NHMRC Clinical Trials Centre, Level 6, Chris O'Brien Lifehouse, 119–143 Missenden Road, Camperdown NSW 2050
Description: This study is a collaboration between the Garvan Institute of Medical Research, the Kinghorn Cancer Centre, Sydney Catalyst and the NHMRC Clinical Trials Centre, University of Sydney. The study is currently open at St Vincent’s Hospital in Darlinghurst, and will soon open at Chris O’Brien Lifehouse and St George’s Hospital in Sydney.
The study is led by Professor David Thomas (Garvan Institute of Medical Research, The Kinghorn Cancer Centre) and Professor John Simes (NHMRC Clinical Trials Centre).
The explosion in genomic capacity presents the opportunity to molecularly phenotype cancers in unprecedented detail. Genomic screening tools are increasingly used to guide therapeutic decisions for individual patients, yielding the notion of ‘precision’ medicine.  
The MoST Study uses novel genomics and other molecular assays for therapeutic targets, to identify ‘actionable’ mutations for patients with advanced cancers of any kind, but with a particular focus on rare cancers. The MoST then offers multiple, parallel, signal-seeking trials of novel drugs to patents in whom an ‘actionable’ target is found.
Contact: most@ctc.usyd.edu.au

Trial Name: A Phase II, Open-Label, Multicenter Trial to Investigate the Clinical Activity and Safety of Avelumab (MSB0010718C) in Subjects With Merkel Cell Carcinoma
Locations:     Lismore Base Hospital, New South Wales
                       Royal North Shore Hospital, New South Wales
Contact:        Adam Boyce, 02 6629 4559, aboyce@oncnorthcoast.com.au
                       Alexander Guminski, 02 9911 7210, alexander.guminski@health.nsw.gov.au

Trial Name: A parallel group randomised, controlled, multi-centre phase II open label trial with two cohorts testing the combination of capecitabine and temozolomide (CAPTEM) and peptide receptor radionuclide therapy (PRRT) for the treatment of advanced pancreatic or midgut neuroendocrine tumours that are not suitable for surgery.  (ACTRN12615000909527)
Location: GI Cancer Institute @ Lifehouse, Level 6, 119-143 Missenden Road, Camperdown NSW 2050
Contact: controlnets@ctc.usyd.edu.au

Trial Name: A Phase II Trial of Ipilimumab and Nivolumab for the Treatment of Rare Cancers (NCT02923934)
Location: Olivia Newton John Cancer Research Centre, Heidelberg, Victoria
Contact: Teresa.Morgan@onjcri.org.au

Trial Name: NABNEC - A Randomised Phase II Study Of nab-paclitaxel In Combination With Carboplatin As First Line Treatment Of Gastrointestinal Neuroendocrine Carcinomas (ACTRN12616000958482)
Locations:       Royal North Shore Hospital, St Leonards, New South Wales
                         Westmead Hospital, Westmead, New South Wales
                         Calvary Mater Newcastle Hospital, Newcastle, New South Wales
                         Monash Medical Centre, Moorabbin, Victoria
                         Fiona Stanley Hospital, Murdoch, Western Australia
                         Royal Hobart Hospital, Hobart, Tasmania
Contact: Dr Mustafa Khasraw nabnec@ctc.usyd.edu.au 
For further locations, additional information and contact details, please click here

Trial Name: InterAACT - An International Multicentre Open Label Randomised Phase II Advanced Anal Cancer Trial Comparing Cisplatin plus 5-fluorouracil versus Carboplatin plus Weekly Paclitaxel in Patients with Inoperable Locally Recurrent or Metastatic Disease (ACTRN12616000061437)
Location: Flinders Medical Centre - Bedford Park, South Australia
Contact: Dr Amitesh C Roy - interAACT@ctc.usyd.edu.au
For further locations, additional information and contact details, please click here

Trial Name: A Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of GSK525762 in Subjects With NUT Midline Carcinoma (NMC) and Other Cancers (NCT01587703) 
Location: Clayton, Victoria, 3168
Contact: arun.azad@monash.edu

Trial Name: AN OPEN-LABEL, MULTICENTRE, GLOBAL PHASE 2 BASKET STUDY OF ENTRECTINIB FOR THE TREATMENT OF PATIENTS WITH LOCALY ADVANCED OR METASTATIC SOLID TUMORS THAT HARBOR NTRK 1/2/3, ROS1, OR ALK GENE REARRANGEMENTS
Location: Border Medical Oncolgy Albury, New South Wales
Contact: dlong@bordermedonc.com.au
For further locations and contact details, please click here